WebFeb 1, 2024 · The agency granted breakthrough designations to 213 devices in 2024, for a total of 617 total breakthrough designations since the program began in 2015. Out of those, 13 breakthrough requests received marketing authorization: three premarket approval applications, three 510(k)s and seven de novo requests. Web3-6 Breakthrough behavior of multisolute systems: (a) effect on target compound breakthrough and (b) DOM breakthrough as measured by DOC ..... 26 3-7 Common GAC application points ..... 27 4-1 Richard G. Miller Treatment Plant TTHM concentration through the
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