Calsyntenin 3β clstn3β
WebCalsyntenin-3 (Clstn3) is a postsynaptic adhesion molecule that induces presynaptic differentiation via presynaptic neurexins (Nrxns), but whether Nrxns directly bind to … WebMoreover, Zeng et al. show that a previously unknown protein, named calsyntenin 3β (CLSTN3β), promotes the sympathetic innervation of both brown and beige adipocytes [91]. CLSTN3β binds to and ...
Calsyntenin 3β clstn3β
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WebABS2236-25UG. Description. Anti-CLSTN3b. Background Information. Calsyntenin 3beta (UniProt: A0A4P8DYG6; also known as Calsyntenin-3β, CLSTN3β) is encoded by the … WebCalsyntenin 3β (CLSTN3β) is a mammal-specific membrane protein that promotes the sympathetic innervation of brown and beige adipocytes by binding to S100b, which in turn acts as a neurotrophic factor to stimulate sympathetic axon growth. CLSTN3β localizes to the endoplasmic reticulum; this interaction enables it to enhance secretion of S100b ...
Webof calsyntenin 3β, and forced expression of S100b in brown adipocytes rescues the defective sympathetic innervation that is caused by ablation of calsyntenin 3β. Our data re veal a mammal-specific mechanism of communication between ... named calsynt enin 3β (CLSTN3β ), promotes the sympathetic inner - vation of both brown and beige ... WebIn striking contrast to the known form of Clstn3, a completely distinct and unannotated form is expressed in BAT, which we have named Calsyntenin-3β (Clstn3β) (Fig. 1a). …
WebNov 2, 2024 · Similarly, calsyntenin-3β (CLSTN3β) binds to and enhances the expression of neurotrophic factor S100b, which in turn encourages local sympathetic growth and arborization (Zeng et al., 2024). CLSTN3β silencing or upregulation reduces or enhances sympathetic innervation in BAT, respectively, and CLSTN3β ablated subjects on a high … WebCalsyntenin 3beta (UniProt: A0A4P8DYG6; also known as Calsyntenin-3β, CLSTN3β) is encoded by the Clstn3 (also known as Clstn3b) gene (Gene ID: 232270) in murine …
WebAblation of calsyntenin 3β predisposes mice on a high-fat diet to obesity. Mechanistically, calsyntenin 3β promotes endoplasmic-reticulum localization and secretion of S100b-a protein that lacks a signal peptide-from brown adipocytes. S100b stimulates neurite outgrowth from sympathetic neurons in vitro. A deficiency of S100b phenocopies ...
WebJul 22, 2024 · Of note, a recent discovery from Spiegelman’s group has identified calsyntenin 3β (Clstn3β), which is a thermogenic fat-specific protein located in the endoplasmic reticulum. It enhances the secretion of S100b in response to cold, which promotes sympathetic innervation and thereby improves non-shivering thermogenesis . dickinson college early decisionWebcalsyntenin 3β (CLSTN3β), found in brown fat cells, acts as a crucial regulator of BAT inner - vation and thermogenesis by controlling the secretion of a growth factor, the protein S100b. A key regulator of BAT thermogenesis is the sympathetic nervous system3, which mediates neuronal and hormonal responses citra fairness creamWebCorrections. All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:590:y:2024:i:7845:d:10.1038_s41586-020-03161-z.See general information about how to correct material in RePEc.. For technical … citra fastest buildWebCalsyntenin 3beta (UniProt: A0A4P8DYG6; also known as Calsyntenin-3β, CLSTN3β) is encoded by the Clstn3 (also known as Clstn3b) gene (Gene ID: 232270) in murine species. CLSTN3β is a mammal-specific that is preferentially expressed in thermogenic adipocytes and is localized in endoplasmic reticulum. Its expression in brown adipose tissue is ... citrafleet fachinformationWebSep 25, 2024 · Activation of thermogenic adipose tissue is linked to improved metabolic outcomes in mice and humans. Dissipation of energy as heat during thermogenesis … dickinson college early actionWebMay 1, 2024 · Europe PMC is an archive of life sciences journal literature. dickinson college directoryWeb詳細. Calsyntenin 3beta (UniProt: A0A4P8DYG6; also known as Calsyntenin-3β, CLSTN3β) is encoded by the Clstn3 (also known as Clstn3b) gene (Gene ID: 232270) in … citrafleet bowel prep