Cholangioids
WebSep 11, 2024 · Europe PMC is an archive of life sciences journal literature. WebApr 10, 2024 · Similarly, in a 3D organoid model using PSC cholangiocytes, these “cholangioids” displayed senescent and SASP features, which promoted macrophage recruitment and number. The role of senescence/SASP in biliary injury has been demonstrated; thus, evaluation of targeting this axis for therapeutic use is of great interest.
Cholangioids
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Web1 day ago · Apr 13, 2024 (Prime PR Wire via Comtex) -- This “Primary Biliary Cholangitis Treatment Market" highlights key external drivers that affect the industry... WebSep 1, 2024 · Cholangioids exposed to hydrogen peroxide exhibited cellular senescence and the senescence-associated secretory phenotype (SASP; increased IL-6, p21, SA‐β …
WebMar 22, 2024 · These cholangioids could be used for further research, including as a 3D model for PSC in vitro. Exosomes were derived from hPMSCs and co-cultured with … WebSep 11, 2024 · Cholangioids are functionally active, and upon secretin stimulation, luminal size increased by ~80%. Cholangioids exposed to …
WebMar 3, 2024 · To examine this concept, we cultured epithelial cell adhesion molecule–positive reactive cholangioids (ERCs) obtained from wild-type (WT), Tr −/−, Mdr2 −/− and DKO mice. Single-cell transcriptomics and immunostaining of both WT and DKO ERCs confirmed their DR-cell phenotype. WebDevelopment and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis. Lorena Loarca, Thiago M. De Assuncao, Nidhi Jalan-Sakrikar, Steve Bronk, Anuradha Krishnan, Bing Huang, Leslie Morton, Christy Trussoni, Lorena Marcano Bonilla, Eugene Krueger, ...
WebCholangioids are functionally active, and upon secretin stimulation, luminal size increased by ~80%. Cholangioids exposed to hydrogen peroxide exhibited cellular senescence and the senescence-associated secretory phenotype (SASP; increased IL-6, p21, SA‐β-Gal, yH2A.x and p16 expression). Furthermore, cholangioids derived from NHC-sen or PSC
WebSep 27, 2024 · These cholangioids of primary, nontransformed tissues grow as 3D structures, accurately recapitulate tissue architecture by providing cell-to-cell contact, … dave haskell actorWebFurthermore, cholangioids derived from NHC-sen or PSC patients were smaller and had slower growth than the controls. When co-cultured with THP-1 macrophages, the number of macrophages associated with NHC-sen or PSC cholangioids was five- to seven-fold greater compared to co-culture with non-senescent NHC. We observed that NHC-sen … dave harlow usgsWebphenotype (cholangioids), which were characterized as suitable 3D models of bioengineered biliary tissue.26 How-ever, utilization of isolated cholangiocytes remains subop-timal, encouraging alternative sources. Hepatocytes. Hepatocyte-to-cholangiocyte transdiffer-entiation has been evidenced by an increase of cells dave hatfield obituaryWebDownload scientific diagram hPMSC-derived exosomes have a protective effect in senescent cholangioids. a Comparison of organoids among the Ctrl, Sen, and Exo … dave hathaway legendsWebWe use these models to investigate whether PSC cholangiocytes are intrinsically predisposed to cellular senescence. Skin fibroblasts from healthy controls and subjects … dave harvey wineWebMar 22, 2024 · Cholangioids were collected and analyzed at 48, 72, and 120 h. e Presence of the exosome-specific marker CD9 (red) in cholangioids (CK19, green) of the Exo … dave harkey construction chelanWebSep 27, 2024 · Major physiologic functions of cholangiocytes include modification of the bile, the formation of a barrier between biliary constituents in the bile duct lumen and the tissue surrounding the bile duct, and providing access to the immune and vascular systems in the peribiliary space. dave harrigan wcco radio