Web16 apr. 2010 · Previous reports showed gastric cancers harbored mutations of FGFR2 and ErbB2, but c-Met oncogenic mutation had not yet been reported. We performed mutational analysis of the cytoplasmic domains of c-Met using the genome DNA of the gastric cancer cell lines, and found that Hs746T cells had a splice site mutation of exon 14. Web29 nov. 2024 · Results Merestinib inhibited Hs746t cell proliferation (IC50=34 nM) and totally eliminated pMET at 100nM. Emibetuzumab showed little anti-proliferative activity against Hs746t cells ... IGF1R, INSR pathways as determinants of lapatinib unresponsiveness in HER2-positive gastric cancer. Clin Cancer Res 20(17):4559–4573.
Gastric cancer cell line Hs746T harbors a splice site mutation of c …
Web9 mrt. 2024 · The HER2-targeting antibody trastuzumab in combination with platin-fluoropyrimidine is the standard of care for patients with HER2 positive advanced gastric … WebHs746T xenograft model Gastric cancer is the third prevalent cause of cancer deaths worldwide and remains a disease with high mortality. Advanced gastric cancer frequently has a poor prognosis as it is resistant to many of the conventional chemotherapeutic strategies. Average age at diagnosis is 69 years, and the risk is slightly higher in men […] homeostasis翻译
Gastric cancer cell line Hs746T harbors a splice site …
Web26 sep. 2024 · The gastric cancer cell line Hs746T (ATCC) was cultured at 37°C in humidified atmosphere with 5% CO 2. Cells were grown in Dulbecco’s Modified Eagle Medium with GlutaMAX (Thermo Fisher Scientific) with 0.5% penicillin/streptomycin (Thermo Fisher Scientific) and 10% Sera Plus (Pan Biotech). Web31 mrt. 2024 · GEO help: Mouse over screen elements for information. Effects of EGF, cetuximab, trastuzumab and afatinib on gene expression in gastric cancer cell lines. The antibody trastuzumab in combination with platin-fluoropyrimidine chemotherapy is the standard of care for patients with HER2-positive recurrent or metastatic gastric cancer. WebHs746T cell movement was tracked for 7 hours. The position of one exemplary cell in 30 minute intervals is depicted. The red line indicates the trajectory of the cell. Source … homeosutajia