Incb 057643
WebApr 28, 2024 · INCB057643 Clinical Trials, 3 Results, Page 1 WebThis open-label, single-arm, two-part, phase 1 study (INCB 57643-103, NCT04279847) is designed to further evaluate the safety, tolerability, and preliminary efficacy of INCB057643 monotherapy in patients with relapsed or refractory MF In total, approximately 15 patients are anticipated to be enrolled
Incb 057643
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WebClassical BCR-ABL-negative myeloproliferative neoplasms (MPN) are a heterogeneous group of hematologic malignancies, including essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF), as well as post-PV-MF and post-ET-MF. Progression to more symptomatic disease, such as overt MF or acute leukemia, represents one of the … Methods: INCB 57643-103 (NCT04279847) is a phase 1, single-arm, open-label, two-part dose confirmation and expansion study evaluating INCB057643 in patients with measurable histologically or cytologically confirmed (World Health Organization criteria 2016), relapsed or refractory primary MF or secondary MF (post-polycythemia vera, post ...
WebINCB-057643 is a novel, orally bioavailable BET inhibitor. JavaScript seems to be disabled in your browser. You must have JavaScript enabled in your browser to utilize the …
WebIn the first-in-human study INCB 57643-101, the BET inhibitor INCB057643 was generally safe and tolerable as monotherapy, and demonstrated preliminary efficacy in a small number of patients with MF, as monotherapy or combined with the JAK inhibitor, ruxolitinib (Falchook G, et al. Clin Cancer Res. 2024). Aims WebDescription INCB-057643 is a novel, orally bioavailable BET inhibitor. IC₅₀ & Target BET[1] INCB-057643 is a novel, orally bioavailable BET inhibitor. INCB-057643 inhibits binding of BRD2/BRD3/BRD4 to an acetylated histone H4 peptide in the low nM range, and is selective against other bromodomain containing proteins. In vitro analyses
WebINCB057643 (INCB 057643) Catalog No.: PC-63272 Not For Human Use, Lab Use Only. INCB057643 is a novel potent, selective, orally bioavailable BET inhibitor. Packing Price Stock Quantity; 25 mg: $478: In stock: 100 mg: $1580: In stock: 250 mg: Get quote: 1 g: Get quote Get Quotation Now ...
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