Receptor lipophagy
Webb结合 in vitro 、 in cell 和基因敲除小鼠的种种证据表明， ORP8 是一个介导脂滴自噬的受体蛋白 （ lipophagy receptor ）。 作者首先从细胞中分离脂滴，通过与纯化的 LC3B 蛋白孵育， HPLC-串联质谱筛选到 ORP8 与 … Webb3 mars 2024 · Studies with receptor-selective agonists revealed that oxysterol receptors (LXRs) and the bile acid receptor, FXR, are the RXR heterodimeric partners that mediate these effects by regulating expression of the reverse-cholesterol transporter, ABC1 ( 600046 ), and the rate-limiting enzyme of bile acid synthesis, CYP7A1, respectively.
Receptor lipophagy
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WebbThe autophagic degradation of lipid droplets (LDs), termed lipophagy, is a major mechanism that contributes to lipid turnover in numerous cell types. While numerous … Webb7 dec. 2024 · Lipophagy, the selective engulfment of lipid droplets (LDs) by autophagosomes for lysosomal degradation, is critical to lipid and energy homeostasis. …
WebbThis review summarizes the latest knowledge on the regulatory mechanism of ferroptosis and its roles in fibrotic diseases Webb9 feb. 2024 · The LD localization and facilitation of lysosomal LD turnover raised the possibility that ORP8 acts as a lipophagy receptor. An essential property of an …
Webb17 aug. 2024 · There was hepatic oxidative stress with increased lipid peroxidation and changes in antioxidant enzyme expression in both models, while apoptosis and autophagy were both evident in HH mice, suggesting they contribute to liver injury processes in iron overload disease. WebbCreated an in vitro model of inflammation mediated by mitochondrial fragmentation in microglia from transgenic mice for a EU collaborative project Set up instrumentation for measuring live cell...
Webbför 17 timmar sedan · [求助补充材料] Guanine Nucleotide‐Binding Protein G(i) Subunit Alpha 2 Exacerbates NASH Progression by Regulating Peroxiredoxin 1–Related …
Webbför 2 dagar sedan · Intracellular complement — the complosome — serves non-classical roles as a novel central regulator of basic cell physiological processes including mitochondrial respiration, glycolysis ... jd \u0026 roisinWebbLipophagy is the process of selective degradation of lipid droplets (LDs) by autophagy. Several studies have highlighted the importance of lipophagy in regulating cellular lipid … jd \u0026 la trucking incWebbför 17 timmar sedan · G-Proteins and GPCRs: From the Beginning Hetero-oligomerization and Specificity Changes of G Protein-Coupled Purinergic Receptors Targeted, Regulatable Expression of Activated Heterotrimeric G Protein α Subunits in Transgenic Mic... G Protein-Mediated Signalling Pathways Gs Family of Heterotrimeric G Proteins jd \\u0026 lj transportWebbför 22 timmar sedan · Structures of TNF Receptors and Their Interactions With Ligands Oxidative Damage and Repair of Human Erythrocyte Lipids Phospholipase D: A New Avenue to the Phospholipid Signalling Pathways in the Myocardium Lipid metabolism in photoreceptor membranes: regulation and mechanisms. la adana massachusettsWebb8 feb. 2024 · Lipophagy: a novel type of lipid catabolism Lipid metabolism is a complex metabolic process that includes digestion, absorption, synthesis, catabolism and … jd \u0026 lj transportWebb19 aug. 2024 · Lipid droplets (LDs) are crucial organelles for energy storage and lipid homeostasis. Autophagy of LDs is an important pathway for their catabolism, but the … jd\u0026s epbm teapotWebb1 feb. 2024 · The role of lipophagy in cancer is poorly understood, although analysis of specific autophagy receptors has helped to expand the diversity of chemotherapeutic … la adaptacion darwin